View documents (PDF) of following L-Tryptophan information.


Appearance: White, light brown crystals

  • Molecular Formula: C11H12N2O2
  • Molecular Weight: 204.23
  • Structure of Tryptophan:

Tryptophan is an indispensable amino acid as well as the fourth limiting amino acid in most swine diets [beyond Lysine, Methionine, and threonine]. The commercial introduction and use of crystalline feed grade L-Tryptophan has provided nutritionists with a tool that allows them to economically balance dietary protein and meet the amino acid requirements of today’s high-yielding livestock. Tryptophan is especially limiting for swine diets that are corn-sbm based and high levels of DDGS, since corn protein is deficient in tryptophan.



Chemical Formula: C11H12N2O2

Molecular Weight: 204.23

Percent Nitrogen: 13.45%

Description: Yellowish-white crystalline powder

Solubility in H2O: 1.136 g/ 100g water at 20ºC

Loss on Drying: 1.0% (Max)

Purity: 98.0% (Min)

Bulk Density kg/L: 0.20 – 0.30


L-Tryptophan content: 98.0%

Crude Protein (%/16 g-N): 84.0%

Energy Guarantee Mean
Swine2, DE 6510 (kcal/kg) 2950 (kcal/lb)
Swine2, ME 6120 (kcal/kg) 2780 (kcal/lb)
Swine2, NE 4730 (kcal/kg) 2150 (kcal/lb)
Poultry3, ME 5850 (kcal/kg) 2650 (kcal/lb)


Shelf Life (unopened packaging) – 3 years (20 kg bags); 1 year (500 kg totes)

Pelleting stability – Stable under commercial pelleting conditions


Tryptophan 20 kg bags:

Pallet size – 40″ x 48″ (1.02 m x 1.22 m)

Stack pattern - 5 bags/layer; 10 bags high; Pallet Weight – 1000 kg (2,205 lbs.)

Pallet dimensions (stacked) – Width 40″ x Depth 48″ x Height 54″ (1.02 m x 1.22 m x 1.37 m)

Tryptophan 500 kg Tote:

Pallet size – 40″ x 48″(1.02 m x 1.22 m)

Tote Dimensions (Type D Chromiq Blue) – 91cm x 91cm x 90cm

Loop Size – (10.75″) Standard lift loops on all four (4) corners

Spout Dimensions – 36 cm (14″) diameter, 46 cm (18″) length

1. The Merck Index, 13th Edition (2001)

2. J. Noblet, INRA, France (Personal communications, 2000)

3. Larbier, INRA, France

The information contained herein is correct to the best of our knowledge. The recommendations or

suggestions made in this document are made without guarantee or representation as to result.

For animal feed only – not for human consumption


1.1. Product identifier
Trade Name: L-Tryptophan 98% Feed Grade
1.2. Relevant identified uses of the product
Indentified uses: This product shall exclusively be used in animal nutrition. It shall not be used for any food application
1.3. Identification of the Company
Manufacturing and Distributer:
Ajinomoto Health & Nutrition North America, Inc.
1116 Hwy 137
Eddyville, Iowa 52553
Phone: 641-969-4551 - Eddyville IA
773-380-7000 - Chicago, IL.

2.1. Classification of the substance or mixture
Not a hazardous substance or mixture according to Regulation (EC)No 1272/2008.
Not a hazardous substance or mixture according to Directive 67/548/EEC
2.2. Label Elements
Labeling according to regulation (EC) No 1272/2008 [EU-GHS/CLP]

Signal Word: Warning
Hazard Statement: May form combustible concentration in air
H335: May cause respiratory irrittation
Labeling according to Directive 67/548/EEC
Symbol (s): None Defined
2.3. Other Hazards:None


Components: Concentration
L-Tryptophan content 98% (on a dry matter basis)
Curd Protine (%/16 g-N) 84% (on a dry matter basis)
(S)-α*amino-1-H-indole-3-propanoic acid (The Merck Index)
1-α-aminoindole-3-propionic acid (The Merck Index)
1- α-αmino-3-indolepropionic acid (The Merck Index)
2-amino-3-indolylpropanoic acid (The Merck Index)
1-β-3-indolylalanine (The Merck Index)
Chemical Formula:C11H12N2O2
No CAS: 73-22-3
No EINECS: 200-795-6

4.1. Description of first aid measures
If inhaled
In case of breathing trouble, immediately relocate to a fresh air environment. Seek medical attention.
In case of skin contact
In case of exposure, wash with soap and copious amounts of water. If irritation persists, seek medical attention.
In case of eye contact
Flush eyes with copious amounts of water for at least 15 minutes. Ensure adequate flushing by separating eyelids with fingers. If contact lenses are worn, remove lenses and continue rinsing. Seek medical attention.
If swallowed
Rinse mouth with water. If any trouble appears, seek medical attention.
4.2. Most important symptoms and effects, both acute and delayed
No data available
4.3. Indication of any immediate medical attention and special treatment needed
No data available

5.1. Extinguishing media
Water spray, carbon dioxide, dry chemical powder/foam.
5.2. Special hazards arising from substance or mixture
Warning - Product may form combustible concentrations when dispersed in air
5.3. Advice for firefighters
Wear protective clothing and breathing mast to protect from fumes
5.4. Further information
No data available

6.1. Personal precautions, protective equipment and emergency procedures
(See paragraph 8).
6.2. Environmental precautions
In case of release in large quantities, avoid releasing in sewers and water courses.
6.3. Methods and materials for containment and cleaning
Prevent spills from entering sewers and water courses.
Avoid dust generation and ventilate the area. Collect the product and place it in bags or containers for later disposal and elimination as waste, according to local legislation. After material has been removed, rinse the spill site with water.

7.1. Precautions for safe handling
Follow good manufacturing practice and personal hygiene.
Standard precautions for powdered products or products generating dust:
  -  Avoid dust dispersion during grinding or blending operations
  -  Provide mechanical exhaust or ventilation
  -  Clean and eliminate dust from equipment regularly
  -  Use anti-static equipment
  -  Avoid heat sources and sparks.
7.2. Conditions for safe storage, including any incompatibilities
In the bags in which the product has been delivered.
Keep in dry conditions.
Keep away from ignition and heat sources. Avoid exposure to electrostatic discharge.
7.3. Specific end uses
No data available

8.1. Control Parameters
Components with workplace control parameters
Does not contain any substance subject to an exposure limit value.
8.2. Exposure controls
Engineering controls
No data available
Personal protective equipment

Eye/face protection Wear safety goggles in case of direct contact
Body protection Wear protective clothes covering skin. Discard or wash protective clothes after exposure to dust of the product.
Skin protection Wear gloves, especially in case of extended contact
Respiratory protection Wear a mask covering both nose and mouth.
Signal Word Warning
Precautionary Statement P261: Avoid breathing dust
P305+351+383: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present

9.1. Information on basic physical and chemical properties

Appearance yellowish - White, crystalline powder
Odor No particular odor
pH 4.5 to 7 (5% solution)
Apparent Specific gravity 0.2 to 0.3 kg/l
Water solubility 20°C: 1.136 g/ 100g
Partition coefficient: n-octanol / water Log Pow = -1.04
Auto ignition 700°C [measure according to standards IEC-1241-2-1
Part 2, method B and EN 50281-2-1 (2000)]
Minimum ignition energy MIE: 2.4 mj
Cloud temperature MCIT:>580°C
Explosive properties Pmax:8.1 bars
Kst: 250 bar.m.s-1
MEC:56 g/m3
The product is classified as an ST1 hazard
9.2. Other safety information
Warning: May form combustible concentrations ini air when dispersed.

10.1. Reactivity
Exothermic reaction between 340°C and 360°C
10.2. Chemical stability
Stable if stored in dry conditions.
10.3. Possibility of hazardous reactions
Warning: May form combustible concentrations in air when dispersed.
10.4. Conditions to avoid
Avoid electrostatic sparks and ignition sources.
10.5. Incompatible materials
No data available on incompatible materials.
10.6. Hazardous decomposition products
No data available

11.1. Acute toxicity
Acute oral toxicity: Not harmful when ingested: acute oral LD50 > 2000mg/kg in rat.
Acute inhalation toxicity: Not harmful when inhaled: LC50 ≥ 5.26 g/m3 in rat.
11.2. Skin corrosion / irritation
'L-Tryptophan, technically pure' is not irritating to (human) skin (according to EC standards, OJEC, L 110 A, Vol 36, 4 May 1993)
11.3. Serious eye damage / eye irritation
'L-Tryptophan, technically pure' is not irritation to (human) eyes (according to EC standards, OJEC, L 110 A, Vol 36, 4 May 1993).
11.4. Respiratory or skin sensitization.
Not sensitizing for the skin(LLNA test)
11.5. Germ cell mutagenicity
Not mutagenic (Bacterial reverse mutation test, Gene nutation test at the TK-locus of L5178Y cells, Chromosomal aberration test in cultured Chinese hamster Ovary (CHO) cells). In vitro micronucleus test in cultures human lumphocytes, Bone marrow ('in vivo')micronucleus test incorparated in a repeated- dose(13 week)oral toxicity study in rats.
11.6. Carcinogenicity
Not carcinogenic
11.7. Reproductive toxicity
To the best knowledge of Ajinomoto, no effect on fetal development. 11.8. Specific target organ toxicity – single exposure
No data available
11.9. Specific target organ toxicity – repeated exposure
No data available
11.10. Aspiration hazard
No data available
11.11. Signs and symptoms of exposure
No data available
11.12. Additional information
NOAEL (No adverse effect level, oral administration) is conservatively: 628 mg/kg bw (90 day ingestion rats).

12.1. Toxicity
Not toxic for animal and plant.
12.2. Persistence and degradability
12.3. Bioaccumulative potential
12.4. Mobility in soil
No data available.
12.5. Results of PBT and vPvB assessment
No data available
12.6. Other adverse effects
When a large quantity of the product is released in a river or waste treatment plant, the ecosystem or the functioning of the plant may be disturbed due to increased demand in oxygen required to degrade the product (increase of the biological oxygen demand – BOD - of water)

13. Disposal Consideration
Waste treatment methods
Treat wastes in accordance with the local // national legislation and or environmental regulations that apply.

14. Transport Information
14.1. UN Number
ADR / RID: -     IMDG: -     IATA: -
14.2. UN proper shipping name
ADR / RID: Not dangerous goods     IMDG: Not dangerous goods     IATA: Not dangerous goods -
14.3. Transport hazard class (es)
ADR / RID: -     IMDG: -     IATA: -
14.4. Packing group
ADR / RID: -     IMDG: -     IATA: -
14.5. Environmental hazards
ADR / RID: No     IMDG Marine pollutant: No     IATA: No
14.6. Special precautions for user
No data available

15.1. Safety, health and environmental regulations / legislation specific for the substance or mixture
‘L-Tryptophan, technically pure’ (Commercial name: L-Tryptophan 98% Feed Grade is in the scope of Regulation (EC) No 1831 / 2003 of 22 / 09 / 2003 on additives for use in animal nutrition (OJ EU n◦ L 268 of 18 / 10 / 2003), category: “nutritional additives”, functional group: “amino acids, their salts and analogues”. It is approved for all animal species.
15.2. Chemical Safety Assessment
No data available